This page and data include information for a specific MSK annual disclosure period (January 1, 2019 through disclosure submission in spring 2020). [1], Thompson’s laboratory undertakes basic research in the fields of cancer biology and immunology. Dr. Thompson also holds an equity stake in Agios Pharmaceuticals, a cancer start-up he founded based on research he conducted at the University of Pennsylvania before joining Memorial Sloan Kettering.
[12][13][14][15] His work has also led to new insights into how intracellular metabolite levels can contribute to the regulation of gene expression, cellular differentiation and oncogenic transformation. “The steps that have been made and taken since the meeting by our leadership have addressed the most important concerns to the medical staff and the associate medical staff and really represents a real progress.”, In addition to resigning his board positions, Dr. Thompson also said Tuesday that Memorial Sloan Kettering would give physicians a greater voice in its operations and would conduct an analysis to understand what had gone wrong at the hospital in recent weeks “so that we ensure our path forward is expertly guided by what we learn.”.
Postdoctoral Fellow. Zhu, J., Berisa, M., Schwörer, S., Qin, W., Cross, J. R., & Thompson, C. B.

Nature immunology, 21(9), 1022–1033. Craig B. Thompson, chief executive of Memorial Sloan Kettering Cancer Center, will no longer serve on the board of drug maker Merck. Santosha Vardhana. The move followed two tense meetings at the hospital on Monday, spurred by articles by The New York Times and ProPublica, about insider deals among hospital officials and undisclosed industry relationships. Vardhana, S. A., Hwee, M. A., Berisa, M., Wells, D. K., Yost, K. E., King, B., Smith, M., Herrera, P. S., Chang, H. Y., Satpathy, A. T., van den Brink, M., Cross, J. R., & Thompson, C. B.

(2020). https://www.mskcc.org/.../office-president/craig-b-thompson-biography This hypothesis was formulated to explain how multicellularity might have arisen during evolution. Thompson has studied how genes regulate apoptosis and metabolism, and investigated their application in treating cancer. Thompson became president and chief executive officer of Memorial Sloan Kettering Cancer Center in November 2010. The hospital said last week that a new policy would prohibit compensation in such situations and that the vice president would turn over his stake to the hospital. Dr. Thompson’s decision to leave two boards does not affect the eight other Memorial Sloan Kettering officials who serve on the boards of outside companies.

This article was reported and written in a collaboration with ProPublica, the nonprofit journalism organization.

Schwörer, S., Berisa, M., Violante, S., Qin, W., Zhu, J., Hendrickson, R. C., Cross, J. R., & Thompson, C. B. Thompson, who is 65, received $300,000 in compensation from Merck in 2017, according to company financial filings. (2019). “I believe this is the right decision for Memorial Sloan Kettering and will allow me to redouble my focus on M.S.K. Postdoctoral fellow. Thompson identified the evolutionary duplication of CD28 into CD28 and CTLA-4 and demonstrated that CTLA4 had an inhibitory effect on immune activation. Dr. Thompson said in a memo sent to the hospital staff, exclusive deal the hospital made with an artificial intelligence start-up. Thompson received his bachelor's degree from Dartmouth College and went on to earn his medical degree in 1977 from the University of Pennsylvania Medical School.

Proline biosynthesis is a vent for TGFβ-induced mitochondrial redox stress. n/a- Not available. Genes & development, 10.1101/gad.340661.120. The compensation for the two corporate boards is in addition to what he is paid as chief executive at Memorial Sloan Kettering, the nonprofit institution that is one of the nation's leading cancer centers. [23], In December 2011, The University and its Abramson Family Cancer Research Institute sued Thompson after his move to Memorial Sloan Kettering, charging that he had made use of research conducted at the University of Pennsylvania to start a biotechnology company, Agios Pharmaceuticals that Thompson had co-founded in 2007 while still at the University. 53, No. Dr. Thompson disputed the allegations. After completing his training, Thompson became a physician at the National Naval Medical Center in Bethesda, Maryland, and an assistant professor of medicine at the Uniformed Services University of the Health Sciences.

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(2019).

Over the past month, articles in The Times and ProPublica have outlined leaders’ ties to for-profit companies, including an exclusive deal the hospital made with an artificial intelligence start-up to license images of 25 million tissue slides. Li, A. M., Ducker, G. S., Li, Y., Seoane, J. [25][26], University of Pennsylvania Medical School, Uniformed Services University of the Health Sciences, "Craig Thompson Named President of Memorial Sloan-Kettering", "Leadership | Board or Directors, Founders, Scientific Advisors | Agios", "T-cell proliferation involving the CD28 pathway is associated with cyclosporine-resistant interleukin 2 gene expression", "CD28 activation pathway regulates the production of multiple T-cell-derived lymphokines/cytokines", "bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death", http://nas.nasonline.org/site/Dir/359057457?pg=vprof&mbr=1006672&returl=http%3A%2F%2Fnas.nasonline.org%2Fsite%2FDir%2F359057457%3Fpg%3Dsrch%26view%3Dbasic&retmk=search_again_link/, "The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues", "Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death", "Growth factors can influence cell growth and survival through effects on glucose metabolism", "Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction", "The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate", "Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation", "IDH mutation impairs histone demethylation and results in a block to cell differentiation", "Methods of treating autoimmune disease via CTLA-4Ig", "Methods for selectively stimulating proliferation of T cells", "Bristol-Myers Shells Out $21M To Settle Orencia Suit - Law360", "An Old Idea, Revived: Starve Cancer to Death", "Sloan-Kettering Chief Is Accused of Taking Research", "Suits That Accused Sloan-Kettering Chief of Stealing Research Are Settled", "Penn and Cancer Institute Settle Lawsuits Accusing Scientist of Stealing Research", "2016 Lasker Awards | The Lasker Foundation", "09/19/06, Abramson Cancer Center Director: Craig Thompson - Almanac, Vol.

The compensation for the two corporate boards is in addition to what he is paid as chief executive at Memorial Sloan Kettering, the nonprofit institution that is one of the nation’s leading cancer centers. Li, A. M., Ducker, G. S., Li, Y., Seoane, J. By Paul Goldberg. King, B., Araki, J., Palm, W., & Thompson, C. B. King, B., Araki, J., Palm, W., & Thompson, C. B. (2020).

Thompson’s expertise, perspective and dedication to patient care have contributed greatly to Merck’s mission.

The EMBO journal, 39(8), e103334. Thompson joined the University of Pennsylvania in 1999 as a professor of medicine, the scientific director of The Leonard and Madlyn Abramson Family Cancer Research Institute, and the first chairman of the Department of Cancer Biology. At one meeting with hospital staff, Dr. Thompson apologized for his handling of staff reaction to the issues outlined in the articles, and acknowledged that he had not adequately reined in the industry relationships of the hospital’s former chief medical officer, Dr. José Baselga, who has since resigned. Natasha Pavlova. Yap/Taz promote the scavenging of extracellular nutrients through macropinocytosis.

This is just one more way of ensuring your safety and that of our staff. Craig Thompson resigns from two corporate boards as MSK crisis shifts to board roles. Schwörer, S., Berisa, M., Violante, S., Qin, W., Zhu, J., Hendrickson, R. C., Cross, J. R., & Thompson, C. B.

A task force that was created in the wake of the crisis over conflicts of interest is considering a policy that would prohibit executives from holding such roles, hospital leaders have said.

This work has contributed to the resurgent interest in cancer cell metabolism and may form the basis for translational therapies to exploit the metabolic addictions exhibited by cancer cells.

Center for Molecular Imaging & Nanotechnology, Gerstner Sloan Kettering Graduate School of Biomedical Sciences, Major Trends in Modern Cancer Research 2013: Introduction with Memorial Sloan Kettering’s President and CEO, Major Trends in Modern Cancer Research 2011: Opening Remarks, Major Trends in Modern Cancer Research 2012: Discussion with Memorial Sloan Kettering’s President, Programs for College & High School Students.

[citation needed], Thompson’s discovery of oncogenic metabolites (succinate, fumarate, and 2-hydroxyglutarate) that can inhibit tumor suppressor function and/or impair cellular differentiation has helped lead to the development of new treatments for leukemia, gliomas, sarcomas, and bladder cancer, currently in clinical trials. [8] He published this work alongside Stanley Korsmeyer’s report of the first pro-apoptotic family member, Bax, and together established the three classes of this gene family and defined their pro-apoptotic and anti-apoptotic roles.

Memorial Sloan Kettering’s Chief Executive Resigns From Merck’s Board of Directors. Craig B. Thompson (born 1953) is an American cell biologist and current president of the Memorial Sloan Kettering Cancer Center.


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